FlyBase Allele Report: Dmel\ais[167]

General Information

Symbol

Dmel\ais¹⁶⁷

Species

D. melanogaster

Name

FlyBase ID

FBal0374943

Feature type

allele

Associated gene

Dmel\ais

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

CRISPR/Cas9

Nature of the Allele

Allele class

Mutagen

CRISPR/Cas9

(Chen et al., 2022)

Progenitor genotype

Cytology

Description

Point mutation resulting in loss of amino acids in the ATP-binding site.

(Chen et al., 2022)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased occurrence of cell division | third instar larval stage

(Chen et al., 2022)

lethal - all die before end of pupal stage

(Chen et al., 2022)

Phenotype Manifest In

embryonic/larval salivary gland | third instar larval stage

(Chen et al., 2022)

larval brain | third instar larval stage

(Chen et al., 2022)

nucleolus | third instar larval stage

(Chen et al., 2022)

wing disc | third instar larval stage

(Chen et al., 2022)

Detailed Description

Statement

Reference

In ais¹⁶⁷ homozygous third instar larvae, salivary glands present enlarged nucleoli and the brain and wing discs exhibits fewer mitosis.

(Chen et al., 2022)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

ais¹⁶⁷ has increased mortality during development phenotype, enhanceable by Rrp5^4-2/Rrp5^4-2

(Chen et al., 2022)

NOT Enhanced by

Statement

Reference

ais¹⁶⁷ has lethal - all die before end of pupal stage phenotype, non-enhanceable by Rrp5^11-1/Rrp5^11-1

(Chen et al., 2022)

ais¹⁶⁷ has lethal - all die before end of pupal stage phenotype, non-enhanceable by Rrp5^4-2/Rrp5[+]

(Chen et al., 2022)

NOT suppressed by

Statement

Reference

ais¹⁶⁷ has lethal - all die before end of pupal stage phenotype, non-suppressible by Rrp5^11-1/Rrp5^11-1

(Chen et al., 2022)

ais¹⁶⁷ has lethal - all die before end of pupal stage phenotype, non-suppressible by Rrp5^4-2/Rrp5[+]

(Chen et al., 2022)

NOT Enhancer of

Statement

Reference

ais¹⁶⁷/ais¹⁶⁷ is a non-enhancer of lethal - all die before end of second instar larval stage phenotype of Rrp5^4-2

(Chen et al., 2022)

NOT Suppressor of

Statement

Reference

ais¹⁶⁷/ais¹⁶⁷ is a non-suppressor of lethal - all die before end of second instar larval stage phenotype of Rrp5^4-2

(Chen et al., 2022)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

ais¹⁶⁷

rok1¹⁶⁷

(Chen et al., 2022)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

Open Close