FlyBase Allele Report: Dmel\Rrp5[4-2]

General Information

Symbol

Dmel\Rrp5^4-2

Species

D. melanogaster

Name

FlyBase ID

FBal0374945

Feature type

allele

Associated gene

Dmel\Rrp5

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

amorphic allele - molecular evidence

Mutagen

CRISPR/Cas9

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Chen et al., 2022)

Mutagen

CRISPR/Cas9

(Chen et al., 2022)

Progenitor genotype

Cytology

Description

Introduces an early termination codon, producing a truncated protein of 135aa (compared to the wild type 1431aa).

(Chen et al., 2022)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die before end of second instar larval stage

(Chen et al., 2022)

Phenotype Manifest In

embryonic/larval salivary gland | second instar larval stage

(Chen et al., 2022)

nucleolus | second instar larval stage

(Chen et al., 2022)

Detailed Description

Statement

Reference

Rrp5^4-2 homozygous second instar larval salivary glands present enlarged nucleoli, compared to controls.

(Chen et al., 2022)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

Rrp5^4-2 has lethal - all die before end of second instar larval stage phenotype, non-enhanceable by ais¹⁶⁷/ais¹⁶⁷

(Chen et al., 2022)

Rrp5^4-2 has lethal - all die before end of second instar larval stage phenotype, non-enhanceable by ais[+]/ais¹⁴¹

(Chen et al., 2022)

NOT suppressed by

Statement

Reference

Rrp5^4-2 has lethal - all die before end of second instar larval stage phenotype, non-suppressible by ais¹⁶⁷/ais¹⁶⁷

(Chen et al., 2022)

Rrp5^4-2 has lethal - all die before end of second instar larval stage phenotype, non-suppressible by ais[+]/ais¹⁴¹

(Chen et al., 2022)

Enhancer of

Statement

Reference

Rrp5^4-2/Rrp5^4-2 is an enhancer of increased mortality during development phenotype of ais¹⁶⁷

(Chen et al., 2022)

NOT Enhancer of

Statement

Reference

Rrp5^4-2/Rrp5^4-2 is a non-enhancer of lethal - all die before end of second instar larval stage phenotype of ais¹⁴¹

(Chen et al., 2022)

Rrp5^4-2/Rrp5[+] is a non-enhancer of lethal - all die before end of pupal stage phenotype of ais¹⁶⁷

(Chen et al., 2022)

Suppressor of

Statement

Reference

Rrp5^4-2/Rrp5[+] is a suppressor | partially of increased mortality during development phenotype of ais¹⁴¹

(Chen et al., 2022)

NOT Suppressor of

Statement

Reference

Rrp5^4-2/Rrp5^4-2 is a non-suppressor of lethal - all die before end of second instar larval stage phenotype of ais¹⁴¹

(Chen et al., 2022)

Rrp5^4-2/Rrp5[+] is a non-suppressor of lethal - all die before end of pupal stage phenotype of ais¹⁶⁷

(Chen et al., 2022)

Other

Statement

Reference

Rrp5^4-2, ais¹⁴¹ has lethal - all die before end of larval stage phenotype

(Chen et al., 2022)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Rrp5^4-2

rrp5^4-2

(Chen et al., 2022)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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