FlyBase Allele Report: Dmel\CNT1[FD]

General Information

Symbol

Dmel\CNT1^FD

Species

D. melanogaster

Name

FlyBase ID

FBal0385336

Feature type

allele

Associated gene

Dmel\CNT1

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - molecular evidence

amorphic allele - genetic evidence

Mutagen

CRISPR/Cas9

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Maaroufi et al., 2022)

amorphic allele - molecular evidence

(Maaroufi et al., 2022)

Mutagen

CRISPR/Cas9

(Maaroufi et al., 2022)

Progenitor genotype

Cytology

Description

752bp deletion within CNT1, removing coding exon 1, all of exon 2 and part of exon 3. This deletes 477bp of the open reading frame. An amino acid at the deletion break site is substituted (Tyr to Ser).

(Maaroufi et al., 2022)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

delins

2R:9,082,535..9,083,292 [+]

Comment:

Net deletion of 477 bases in (encoding 129 amino acids) and substitution of a base iat the junction leading to a Y to S substitution in CNT1 . The mapped location of the deletion was deduced from the description, which is at the amino acid level but not at the nucleotide level.

Inserted_sequence:

(Maaroufi et al., 2022)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased rate of copulation

(Maaroufi et al., 2022)

increased size | male

(Maaroufi et al., 2022)

viable

(Maaroufi et al., 2022)

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

CNT1^FD is rescued by CNT1^GFP

(Maaroufi et al., 2022)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

CNT1^FD

cnt1^FD

(Maaroufi et al., 2022)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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