FB2026_03 , released September 17, 2026
Allele: Dmel\ref(2)PLIRm
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General Information
Symbol
Dmel\ref(2)PLIRm
Species
D. melanogaster
Name
FlyBase ID
FBal0385515
Feature type
allele
Associated gene
Dmel\ref(2)P
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
CRISPR/Cas9
(Bhattacharjee et al., 2022)
gene targeting by homologous recombination
(Bhattacharjee et al., 2022)
Progenitor genotype
Cytology
Description

Amino acid replacement: W454A.

(Bhattacharjee et al., 2022)

Amino acid replacement: I457A.

(Bhattacharjee et al., 2022)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
MNV
2L:19,544,807..19,544,809 [+]
Nucleotide change:

TGG19544807GCC

Reported nucleotide change:

TGG?GCC

Amino acid change:

W454A | ref(2)P-PA; W454A | ref(2)P-PB

Reported amino acid change:

W454A

Comment:

One of two amino acid substitutions in mutant. The other is I457A.

(Bhattacharjee et al., 2022)
MNV
2L:19,544,816..19,544,818 [+]
Nucleotide change:

ATT19544816GCC

Reported nucleotide change:

TATT?GGCC

Amino acid change:

I457A | ref(2)P-PA; I457A | ref(2)P-PB

Reported amino acid change:

I457A

Comment:

A four nucleotide substitution (TATT to GGCC) results in an I457A amino acid change. The first base change is a silent substitution. One of two amino acid changes in mutant. The other is W454A.

(Bhattacharjee et al., 2022)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
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      Disease
      Evidence
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      Modifiers Based on Experimental Evidence ( 0 )
      Disease
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      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      ref(2)PLIRm
      (Bhattacharjee et al., 2022)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)