FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\mtmG447D
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General Information
Symbol
Dmel\mtmG447D
Species
D. melanogaster
Name
FlyBase ID
FBal0386319
Feature type
allele
Associated gene
Dmel\mtm
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Hu et al., 2022)
Progenitor genotype
Cytology
Description

Amino acid replacement: G447D.

(Hu et al., 2022)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:6,035,472..6,035,472 [-]
Nucleotide change:

G6035472A

Reported nucleotide change:

G?A

Amino acid change:

G447D | mtm-PA; G447D | mtm-PB

Reported amino acid change:

G447D

(Hu et al., 2022)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  Charcot-Marie-Tooth disease type 4B1
      CEA
      (Hu et al., 2022)
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      model of  Charcot-Marie-Tooth disease type 4B1
      is ameliorated by Hsap\MTMR2UAS.cHa
      (Hu et al., 2022)
      is ameliorated by Pi3K68DGL00159
      (Hu et al., 2022)
      is ameliorated by Pi3K68DHMS01296
      (Hu et al., 2022)
      is ameliorated by Pi3K68DJF01193
      (Hu et al., 2022)
      is ameliorated by Hsap\MTMR2G103E.UAS
      (Hu et al., 2022)
      is ameliorated by Rab11Q70L.UASp.YFP
      (Hu et al., 2022)
      is exacerbated by Rab11S25N.UASp.YFP
      (Hu et al., 2022)
      is ameliorated by RokHMS01311
      (Hu et al., 2022)
      is ameliorated by sqhHMS00830
      (Hu et al., 2022)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      40-B89
      (Hu et al., 2022)
      40A-B89
      (Hu et al., 2022)
      mtmB89
      (Hu et al., 2022)
      mtmG447D
      (Hu et al., 2022)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)