FB2026_02 , released June 18, 2026
Allele: Dmel\14-3-3ζK52N
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General Information
Symbol
Dmel\14-3-3ζK52N
Species
D. melanogaster
Name
FlyBase ID
FBal0387547
Feature type
allele
Associated gene
Dmel\14-3-3ζ
Associated Insertion(s)
TI{TI}14-3-3ζK52N
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
CRISPR/Cas9
(Wan et al., 2023)
Progenitor genotype
Associated Insertion(s)
TI{TI}14-3-3ζK52N
Cytology
Description

Amino acid replacement: K52N.

(Wan et al., 2023)

The human-disease related K52N mutation is knocked into endogenous 14-3-3ζ.

(Wan et al., 2023)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:10,104,810..10,104,810 [+]
Nucleotide change:

A10104810T

Reported nucleotide change:

A?T

Amino acid change:

K52N | 14-3-3zeta-PA; K52N | 14-3-3zeta-PB; K52N | 14-3-3zeta-PC; K52N | 14-3-3zeta-PD; K52N | 14-3-3zeta-PE; K52N | 14-3-3zeta-PF; K52N | 14-3-3zeta-PG; K52N | 14-3-3zeta-PH; K52N | 14-3-3zeta-PI; K52N | 14-3-3zeta-PJ; K52N | 14-3-3zeta-PK; K52N | 14-3-3zeta-PL

Reported amino acid change:

K52N

Comment:

Analogous mutation in human YWHAZ implicated in intellectual disability with brain malformation, autosomal dominant, YWHAZ-related.

(Wan et al., 2023)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  intellectual disability
      CEA
      (Wan et al., 2023)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      This allele represents a human variant implicated in disease.
      (Wan et al., 2023)
      YWHAZ:p.Lys49Asn
      (FlyBase curators, 2019-)
      Variants Synonym(s)
      Associated human disease model(s)
      External database links
      Comments concerning this variant
      Phenotypic Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      14-3-3ζK52N
      Name Synonyms
      Secondary FlyBase IDs
        References (2)