FlyBase Allele Report: Dmel\Tssk[KO]

General Information

Symbol

Dmel\Tssk^KO

Species

D. melanogaster

Name

FlyBase ID

FBal0391009

Feature type

allele

Associated gene

Dmel\Tssk

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - molecular evidence

Mutagen

CRISPR/Cas9

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Zhang et al., 2023)

Mutagen

CRISPR/Cas9

(Zhang et al., 2023)

Progenitor genotype

Cytology

Description

Knockout allele that has a premature stop codon that completely removes the S_TKc kinase catalytic domain.

(Zhang et al., 2023)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

3R:18,599,069..18,599,073 [+]

Comment:

A 5bp deletion in Tss leads to a frameshift and early translation termination.

(Zhang et al., 2023)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased fecundity, with Tssk^S17A

(Zhang et al., 2023)

decreased fecundity, with Tssk^S18A

(Zhang et al., 2023)

female fertile

(Zhang et al., 2023)

male sterile

(Zhang et al., 2023)

male sterile, with Tssk^K60M

(Zhang et al., 2023)

male sterile, with Tssk^S17A.S18A

(Zhang et al., 2023)

male sterile, with Tssk^ΔC

(Zhang et al., 2023)

male sterile, with Tssk^ΔN

(Zhang et al., 2023)

Phenotype Manifest In

cystic bulge

(Zhang et al., 2023)

cystic bulge, with Tssk^K60M

(Zhang et al., 2023)

cystic bulge, with Tssk^T191A

(Zhang et al., 2023)

cystic bulge, with Tssk^ΔC

(Zhang et al., 2023)

cystic bulge, with Tssk^ΔN

(Zhang et al., 2023)

cystic bulge | absent, with Tssk^S17A.S18A

(Zhang et al., 2023)

cystic bulge | absent, with Tssk^S18A

(Zhang et al., 2023)

male germ cell nucleus

(Zhang et al., 2023)

male germ cell nucleus, with Tssk^K60M

(Zhang et al., 2023)

male germ cell nucleus, with Tssk^T191A

(Zhang et al., 2023)

male germ cell nucleus, with Tssk^ΔN

(Zhang et al., 2023)

spermatid

(Zhang et al., 2023)

spermatid, with Tssk^K60M

(Zhang et al., 2023)

spermatid, with Tssk^T191A

(Zhang et al., 2023)

spermatid, with Tssk^ΔN

(Zhang et al., 2023)

spermatozoon | absent

(Zhang et al., 2023)

spermatozoon | absent, with Tssk^K60M

(Zhang et al., 2023)

spermatozoon | absent, with Tssk^S17A.S18A

(Zhang et al., 2023)

spermatozoon | absent, with Tssk^S18A

(Zhang et al., 2023)

spermatozoon | absent, with Tssk^T191A

(Zhang et al., 2023)

spermatozoon | absent, with Tssk^ΔC

(Zhang et al., 2023)

spermatozoon | absent, with Tssk^ΔN

(Zhang et al., 2023)

sperm flagellum

(Zhang et al., 2023)

sperm flagellum, with Tssk^K60M

(Zhang et al., 2023)

sperm flagellum, with Tssk^T191A

(Zhang et al., 2023)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT suppressed by

Statement

Reference

Tssk^KO has male sterile phenotype, non-suppressible by Hsap\TSSK1B^Tssk.cZa

(Zhang et al., 2023)

Tssk^KO has male sterile phenotype, non-suppressible by Hsap\TSSK3^Tssk.cZa

(Zhang et al., 2023)

Tssk^KO has male sterile phenotype, non-suppressible by Hsap\TSSK2^Tssk.cZa

(Zhang et al., 2023)

Tssk^KO has male sterile phenotype, non-suppressible by Hsap\TSSK4^Tssk.cZa

(Zhang et al., 2023)

Tssk^KO has male sterile phenotype, non-suppressible by Hsap\TSSK6^Tssk.cZa

(Zhang et al., 2023)

Phenotype Manifest In

Suppressed by

Statement

Reference

Tssk^KO has male germ cell nucleus phenotype, suppressible by Hsap\TSSK1B^Tssk.cZa

(Zhang et al., 2023)

Tssk^KO has male germ cell nucleus phenotype, suppressible by Hsap\TSSK6^Tssk.cZa

(Zhang et al., 2023)

Tssk^KO has sperm flagellum phenotype, suppressible by Hsap\TSSK1B^Tssk.cZa

(Zhang et al., 2023)

NOT suppressed by

Statement

Reference

Tssk^KO has male germ cell nucleus phenotype, non-suppressible by Hsap\TSSK2^Tssk.cZa

(Zhang et al., 2023)

Tssk^KO has male germ cell nucleus phenotype, non-suppressible by Hsap\TSSK3^Tssk.cZa

(Zhang et al., 2023)

Tssk^KO has male germ cell nucleus phenotype, non-suppressible by Hsap\TSSK4^Tssk.cZa

(Zhang et al., 2023)

Tssk^KO has cystic bulge phenotype, non-suppressible by Hsap\TSSK1B^Tssk.cZa

(Zhang et al., 2023)

Tssk^KO has spermatozoon | absent phenotype, non-suppressible by Hsap\TSSK1B^Tssk.cZa

(Zhang et al., 2023)

Tssk^KO has spermatozoon | absent phenotype, non-suppressible by Hsap\TSSK4^Tssk.cZa

(Zhang et al., 2023)

Tssk^KO has spermatozoon | absent phenotype, non-suppressible by Hsap\TSSK6^Tssk.cZa

(Zhang et al., 2023)

Tssk^KO has spermatozoon | absent phenotype, non-suppressible by Hsap\TSSK3^Tssk.cZa

(Zhang et al., 2023)

Tssk^KO has spermatozoon | absent phenotype, non-suppressible by Hsap\TSSK2^Tssk.cZa

(Zhang et al., 2023)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Tssk^KO is rescued by Tssk^+tZa

(Zhang et al., 2023)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Tssk^KO

dTSSK-

(Zhang et al., 2023)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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