FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\mt:ATPase6TLI-MRP.a
Open Close
General Information
Symbol
Dmel\mt:ATPase6TLI-MRP.a
Species
D. melanogaster
Name
FlyBase ID
FBal0391591
Feature type
allele
Associated gene
Dmel\mt:ATPase6
Associated Insertion(s)
Carried in Construct
PBac{TLI-MRP-mt:ATPase6.a}
Also Known As
TLI-MRP::ATP6
Key Links
Transgenic product class
antisense
(Towheed et al., 2014)
Mutagen
Nature of the Allele
Transgenic product class
antisense
(Towheed et al., 2014)
Mutagen
in vitro construct
(Towheed et al., 2014)
Progenitor genotype
Carried in construct
PBac{TLI-MRP-mt:ATPase6.a}
Cytology
Description

A RNA polymerase III promoter (from 5S rRNA) drives expression of a chimeric RNA that consists of a non-coding leader sequence (from the nuclear-encoded RNaseMRP:RNA gene) and 25bp of sequence complementary to mt:ATPase6 that targets the mt:ATPase6 translational start site. The presence of the NCL sequence targets the RNA to the mitochondrion, where the antisense sequence can act as a translational inhibitor, inhibiting endogenous mitochondrial expression of mt:ATPase6 protein in vivo.

(Towheed et al., 2014)
Allele components
Component
Use(s)
Regulatory region(s)
5SrRNA
Encoded product / tool
mt:ATPase6
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      mt:ATPase6TLI-MRP.a
      Name Synonyms
      Secondary FlyBase IDs
        References (2)