FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\CG10444S56F
Open Close
General Information
Symbol
Dmel\CG10444S56F
Species
D. melanogaster
Name
FlyBase ID
FBal0398928
Feature type
allele
Associated gene
Dmel\CG10444
Associated Insertion(s)
Carried in Construct
P{CG10444.S56F}
Key Links
Genomic Maps

Transgenic product class
missense_variant
(Utsuno et al., 2024)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Utsuno et al., 2024)
Mutagen
in vitro construct
(Utsuno et al., 2024)
Progenitor genotype
Carried in construct
P{CG10444.S56F}
Cytology
Description

The CG10444 promoter drives expression of the CG10444 coding sequence, mutated to carry a S56F amino acid replacement. This change is equivalent to a S74F change in the orthologous human SLC5A6 gene.

(Utsuno et al., 2024)
Allele components
Component
Use(s)
Regulatory region(s)
CG10444
Encoded product / tool
CG10444
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
MNV
2R:20,274,072..20,274,073 [-]
Nucleotide change:

AG20274073TT

Amino acid change:

S56F | CG10444-PA

Reported amino acid change:

S56F

Comment:

Analogous mutation in human SLC5A6 implicated in SLC5A6-related disorders; mutation carried on in vitro construct; site of nucleotide substitution in fly gene inferred by FlyBase curator based on reported amino acid change.

(Utsuno et al., 2024)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  vitamin metabolic disorder
      CEA
      (Utsuno et al., 2024)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      This allele represents a human variant implicated in disease.
      (Utsuno et al., 2024)
      SLC5A6:p.Ser74Phe
      (FlyBase curators, 2019-)
      Variants Synonym(s)
      Associated human disease model(s)
      External database links
      Comments concerning this variant
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to rescue

      CG10444S56F fails to rescue CG10444JR123

      (Utsuno et al., 2024)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      CG10444S56F
      Name Synonyms
      Secondary FlyBase IDs
        References (2)