FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\AtpαESIA
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General Information
Symbol
Dmel\AtpαESIA
Species
D. melanogaster
Name
FlyBase ID
FBal0399312
Feature type
allele
Associated gene
Dmel\Atpα
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
CRISPR/Cas9
(Yang et al., 2023)
gene targeting by homologous recombination
(Yang et al., 2023)
Progenitor genotype
Cytology
Description

Amino acid replacement: Q111E.

(Yang et al., 2023)

Amino acid replacement: A112S.

(Yang et al., 2023)

Amino acid replacement: A119I.

(Yang et al., 2023)

Amino acid replacement: D120A.

(Yang et al., 2023)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
MNV
3R:20,964,095..20,964,098 [+]
Inserted_sequence:

GAGT

Comment:

Leads to Q97E and A98S mutations. A total of four amino acid substitutions in mutant, reported as Q111E, A112S, A119I, D120A. The amino acid numbering of the reference sequence does not match the "standardized amino acid residue numbering" utilized in the publication. Site and nature of nucleotide substitution in mutant inferred by FlyBase curator based on reported amino acid change.

(Yang et al., 2023)
MNV
3R:20,964,119..20,964,123 [+]
Inserted_sequence:

ATCGC

Comment:

Leads to A105I and D106S mutations. A total of four amino acid substitutions in mutant, reported as Q111E, A112S, A119I, D120A. The amino acid numbering of the reference sequence does not match the "standardized amino acid residue numbering" utilized in the publication. Site and nature of nucleotide substitution in mutant inferred by FlyBase curator based on reported amino acid change.

(Yang et al., 2023)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      AtpαESIA
      ESIA
      (Yang et al., 2023)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)