FB2026_02 , released June 18, 2026
Allele: Dmel\RdlI276F-G279S
Open Close
General Information
Symbol
Dmel\RdlI276F-G279S
Species
D. melanogaster
Name
FlyBase ID
FBal0399329
Feature type
allele
Associated gene
Dmel\Rdl
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
CRISPR/Cas9
(Guo et al., 2023)
gene targeting by homologous recombination
(Guo et al., 2023)
Progenitor genotype
TI{TI}Rdl3xP3RFP
(Guo et al., 2023)
Cytology
Description

CRISPR/Cas9-mediated homology-directed repair has resulted in a chromosome with a Rdl locus that carries the I276F and G279S point mutations.

(Guo et al., 2023)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
MNV
3L:9,155,228..9,155,230 [-]
Nucleotide change:

GGA9155230AGT

Amino acid change:

G279S | Rdl-PA; G279S | Rdl-PC; G279S | Rdl-PD; G279S | Rdl-PE; G279S | Rdl-PF; G279S | Rdl-PG

Reported amino acid change:

G279S

Comment:

A G279S amino acid substitution was introduced into Rdl by CRISPR/Cas9-mediated homology-directed repair. An I276F substitution is also present in the line. Site and nature of nucleotide substitution in mutant inferred by FlyBase curator based on reported amino acid change. Nucleotide change not specified.

(Guo et al., 2023)
MNV
3L:9,155,237..9,155,239 [-]
Nucleotide change:

ATA9155239TTT

Amino acid change:

I276F | Rdl-PA; I276F | Rdl-PC; I276F | Rdl-PD; I276F | Rdl-PE; I276F | Rdl-PF; I276F | Rdl-PG

Reported amino acid change:

I276F

Comment:

An I276F amino acid substitution was introduced into Rdl by CRISPR/Cas9-mediated homology-directed repair. A G279S substitution is also present in the line. Site and nature of nucleotide substitution in mutant inferred by FlyBase curator based on reported amino acid change. Nucleotide change not specified.

(Guo et al., 2023)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      RdlI276F+G279S
      (Zhou et al., 2024)
      RdlI276F-G279S
      (Guo et al., 2023)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)