FB2026_02 , released June 18, 2026
Allele: Dmel\shnzf1.2.4.5
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General Information
Symbol
Dmel\shnzf1.2.4.5
Species
D. melanogaster
Name
FlyBase ID
FBal0399366
Feature type
allele
Associated gene
Dmel\shn
Associated Insertion(s)
TI{TI}shnzf1.2.4.5
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
CRISPR/Cas9
(Toraason et al., 2024)
cre recombinase
(Toraason et al., 2024)
Progenitor genotype
Associated Insertion(s)
TI{TI}shnzf1.2.4.5
Cytology
Description

Serines have been substituted for cysteines in zinc fingers 1 and 2 and asparagines replace two histidines in zinc finger 4 and serines have been substituted for two cysteines in zinc finger 5 of endogenous shn. A Disc\RFP3xP3.cUa marker has been removed via P1\cre.

(Toraason et al., 2024)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:11,209,613..11,209,613 [+]
Nucleotide change:

G11209613C

Amino acid change:

C441S | shn-PA; C441S | shn-PB; C441S | shn-PC; C486S | shn-PD; C441S | shn-PE; C486S | shn-PF

Reported amino acid change:

C?S

Comment:

A total of seven residues have been replace in zinc fingers 1,2,4, and 5 of endogenous shn. Three cysteines have been replaced with serines in zinc fingers 1 and 2. Two histidines have been replaced with asparagine in zinc finger 4 and two cysteines have been replaced with serines in zinc finger 5.

(Toraason et al., 2024)
point_mutation
2R:11,209,622..11,209,622 [+]
Nucleotide change:

G11209622C

Amino acid change:

C444S | shn-PA; C444S | shn-PB; C444S | shn-PC; C489S | shn-PD; C444S | shn-PE; C489S | shn-PF

Reported amino acid change:

C?S

Comment:

A total of seven residues have been replace in zinc fingers 1,2,4, and 5 of endogenous shn. Three cysteines have been replaced with serines in zinc fingers 1 and 2. Two histidines have been replaced with asparagine in zinc finger 4 and two cysteines have been replaced with serines in zinc finger 5.

(Toraason et al., 2024)
point_mutation
2R:11,209,706..11,209,706 [+]
Nucleotide change:

G11209706C

Amino acid change:

C472S | shn-PA; C472S | shn-PB; C472S | shn-PC; C517S | shn-PD; C472S | shn-PE; C517S | shn-PF

Reported amino acid change:

C?S

Comment:

A total of seven residues have been replace in zinc fingers 1,2,4, and 5 of endogenous shn. Three cysteines have been replaced with serines in zinc fingers 1 and 2. Two histidines have been replaced with asparagine in zinc finger 4 and two cysteines have been replaced with serines in zinc finger 5.

(Toraason et al., 2024)
point_mutation
2R:11,213,852..11,213,852 [+]
Nucleotide change:

C11213852A

Amino acid change:

H1789N | shn-PA; H1789N | shn-PB; H1789N | shn-PC; H1834N | shn-PD; H1789N | shn-PE; H1834N | shn-PF

Reported amino acid change:

H?N

Comment:

A total of seven residues have been replace in zinc fingers 1,2,4, and 5 of endogenous shn. Three cysteines have been replaced with serines in zinc fingers 1 and 2. Two histidines have been replaced with asparagine in zinc finger 4 and two cysteines have been replaced with serines in zinc finger 5.

(Toraason et al., 2024)
point_mutation
2R:11,213,864..11,213,864 [+]
Nucleotide change:

C11213864A

Amino acid change:

H1793N | shn-PA; H1793N | shn-PB; H1793N | shn-PC; H1838N | shn-PD; H1793N | shn-PE; H1838N | shn-PF

Reported amino acid change:

H?N

Comment:

A total of seven residues have been replace in zinc fingers 1,2,4, and 5 of endogenous shn. Three cysteines have been replaced with serines in zinc fingers 1 and 2. Two histidines have been replaced with asparagine in zinc finger 4 and two cysteines have been replaced with serines in zinc finger 5.

(Toraason et al., 2024)
point_mutation
2R:11,213,889..11,213,889 [+]
Nucleotide change:

G11213889C

Amino acid change:

C1801S | shn-PA; C1801S | shn-PB; C1801S | shn-PC; C1846S | shn-PD; C1801S | shn-PE; C1846S | shn-PF

Reported amino acid change:

C?S

Comment:

A total of seven residues have been replace in zinc fingers 1,2,4, and 5 of endogenous shn. Three cysteines have been replaced with serines in zinc fingers 1 and 2. Two histidines have been replaced with asparagine in zinc finger 4 and two cysteines have been replaced with serines in zinc finger 5.

(Toraason et al., 2024)
point_mutation
2R:11,213,898..11,213,898 [+]
Nucleotide change:

G11213898C

Amino acid change:

C1804S | shn-PA; C1804S | shn-PB; C1804S | shn-PC; C1849S | shn-PD; C1804S | shn-PE; C1849S | shn-PF

Reported amino acid change:

C?S

Comment:

A total of seven residues have been replace in zinc fingers 1,2,4, and 5 of endogenous shn. Three cysteines have been replaced with serines in zinc fingers 1 and 2. Two histidines have been replaced with asparagine in zinc finger 4 and two cysteines have been replaced with serines in zinc finger 5.

(Toraason et al., 2024)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      shnzf1.2.4.5 has visible | adult stage phenotype, enhanceable by Dadj1E4

      (Toraason et al., 2024)
      NOT Enhancer of
      Statement
      Reference

      shnzf1.2.4.5/shnzf1.2.4.5 is a non-enhancer of visible | adult stage phenotype of Scer\GAL4hs.2sev, hepAct.UAS

      (Toraason et al., 2024)
      NOT Suppressor of
      Statement
      Reference

      shnzf1.2.4.5/shnzf1.2.4.5 is a non-suppressor of visible | adult stage phenotype of Scer\GAL4hs.2sev, hepAct.UAS

      (Toraason et al., 2024)
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      shnzf1.2.4.5 has wing vein | ectopic phenotype, enhanceable by Dadj1E4

      (Toraason et al., 2024)
      NOT Enhancer of
      Statement
      Reference

      shnzf1.2.4.5/shnzf1.2.4.5 is a non-enhancer of eye phenotype of Scer\GAL4hs.2sev, hepAct.UAS

      (Toraason et al., 2024)
      NOT Suppressor of
      Statement
      Reference

      shnzf1.2.4.5/shnzf1.2.4.5 is a non-suppressor of eye phenotype of Scer\GAL4hs.2sev, hepAct.UAS

      (Toraason et al., 2024)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      shnzf1,2,4,5
      (Toraason et al., 2024)
      shnzf1.2.4.5
      Name Synonyms
      Secondary FlyBase IDs
        References (1)