FB2026_03 , released September 17, 2026
Allele: Dmel\nAChRα2mir-1017.KO
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General Information
Symbol
Dmel\nAChRα2mir-1017.KO
Species
D. melanogaster
Name
FlyBase ID
FBal0400742
Feature type
allele
Associated gene
Dmel\nAChRα2
Associated Insertion(s)
TI{TI}mir-1017KO
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    TI{TI}mir-1017KO
    Cytology
    Description

    The nAChRα2 host intron that normally includes mir-1017 is constitutively retained in TI{TI}mir-1017KO flies (a single loxP site replaces part of mir-1017 in these flies). Retention of the intron results in a premature stop codon that is predicted to truncate the nAChRα2 protein.

    (Khanal et al., 2024)
    Allele components
    Component
    Use(s)
    Also carries
    loxP
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        nAChRα2mir-1017.KO
        Name Synonyms
        Secondary FlyBase IDs
          References (2)