FlyBase Allele Report: Hsap\PINK1[UAS.cTa.Tag:FLAG]

General Information

Symbol

Hsap\PINK1^{UAS.cTa.Tag:FLAG}

Species

H. sapiens

Name

FlyBase ID

FBal0406888

Feature type

allele

Associated gene

Hsap\PINK1

Associated Insertion(s)

Carried in Construct

P{UAS-hPINK1.T.FLAG}

Key Links

Transgenic product class

cDNA

(Tsai et al., 2018)

wild_type

(Tsai et al., 2018)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Tsai et al., 2018)

wild_type

(Tsai et al., 2018)

Mutagen

in vitro construct

(Tsai et al., 2018)

Progenitor genotype

Carried in construct

P{UAS-hPINK1.T.FLAG}

Cytology

Description

UASt regulatory sequences drive expression of full-length Hsap\PINK1 cDNA, tagged at the C-terminal with Tag:FLAG.

(Tsai et al., 2018)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Hsap\PINK1

Tagged with

Tag:FLAG

epitope tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Parkinson's disease

modeled by Pink1^B9

(Tsai et al., 2018)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Scer\GAL4^da.PU/Hsap\PINK1^{UAS.cTa.Tag:FLAG} is a suppressor of abnormal locomotor behavior phenotype of Pink1^B9

(Tsai et al., 2018)

Scer\GAL4^da.PU/Hsap\PINK1^{UAS.cTa.Tag:FLAG} is a suppressor of flightless phenotype of Pink1^B9

(Tsai et al., 2018)

Scer\GAL4^da.PU/Hsap\PINK1^{UAS.cTa.Tag:FLAG} is a suppressor of decreased cell number | adult stage phenotype of Pink1^B9

(Tsai et al., 2018)

Phenotype Manifest In

Suppressor of

Statement

Reference

Scer\GAL4^da.PU/Hsap\PINK1^{UAS.cTa.Tag:FLAG} is a suppressor of mitochondrion | third instar larval stage phenotype of Pink1⁵

(Tsai et al., 2018)

Scer\GAL4^da.PU/Hsap\PINK1^{UAS.cTa.Tag:FLAG} is a suppressor of mitochondrial crista | third instar larval stage phenotype of Pink1⁵

(Tsai et al., 2018)

Scer\GAL4^da.PU/Hsap\PINK1^{UAS.cTa.Tag:FLAG} is a suppressor of mitochondrial crista junction | third instar larval stage phenotype of Pink1⁵

(Tsai et al., 2018)

Scer\GAL4^da.PU/Hsap\PINK1^{UAS.cTa.Tag:FLAG} is a suppressor of embryonic/larval hypodermal muscle cell | third instar larval stage phenotype of Pink1⁵

(Tsai et al., 2018)

Scer\GAL4^da.PU/Hsap\PINK1^{UAS.cTa.Tag:FLAG} is a suppressor of mitochondrion | adult stage phenotype of Pink1^B9

(Tsai et al., 2018)

Scer\GAL4^da.PU/Hsap\PINK1^{UAS.cTa.Tag:FLAG} is a suppressor of dopaminergic PPL1 neuron | adult stage phenotype of Pink1^B9

(Tsai et al., 2018)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Hsap\PINK1^{UAS.cTa.Tag:FLAG}

Pink1^UAS.Tag:FLAG

Name Synonyms

Secondary FlyBase IDs

FBal0360934
FBal0341847

References (2)

Report Sections

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