FlyBase Allele Report: Dmel\HDAC1[RNAi.UAS.cUa]

General Information

Symbol

Dmel\HDAC1^RNAi.UAS.cUa

Species

D. melanogaster

Name

FlyBase ID

FBal0407440

Feature type

allele

Associated gene

Dmel\HDAC1

Associated Insertion(s)

Carried in Construct

P{UAS-HDAC1.RNAi.U}

Key Links

Transgenic product class

RNAi_reagent

(FlyBase Curators, 2025-)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(FlyBase Curators, 2025-)

Mutagen

in vitro construct

(FlyBase Curators, 2025-)

Progenitor genotype

Carried in construct

P{UAS-HDAC1.RNAi.U}

Cytology

Description

UAS sequences regulate expression of an RNAi line that targets HDAC1.

(FlyBase Curators, 2025-)

FlyBase curator comment: this entry represents a transgenic construct where the particular construct used cannot be determined.

(FlyBase Curators, 2025-)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

HDAC1

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

eye, with Scer\GAL4^GMR.PF

(Bhaskar et al., 2014)

ommatidium, with Scer\GAL4^GMR.PF

(Bhaskar et al., 2014)

Detailed Description

Statement

Reference

Depletion of Rpd3 in the eye-antennal disc, through expression of Rpd3^TRiP.cUa under the control of Scer\GAL4^GMR.PF, leads to a marginal disorganisation of the ommatidia. This is accompanied by upregulation of hid.

(Bhaskar et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

HDAC1^RNAi.UAS.cUa, Scer\GAL4^C-765 is a suppressor | partially of increased mortality during development | heat sensitive phenotype of Hsap\RAF1^L613V.UAS, Scer\GAL4^C-765

(Das et al., 2021)

HDAC1^RNAi.UAS.cUa, Scer\GAL4^C-765 is a suppressor | partially of increased mortality during development | heat sensitive phenotype of Hsap\KRAS^G12D.UAS, Scer\GAL4^C-765

(Das et al., 2021)

Other

Statement

Reference

HDAC1^RNAi.UAS.cUa, Hsap\RAF1^L613V.UAS, Scer\GAL4^C-765 has partially lethal - majority die phenotype

(Das et al., 2021)

HDAC1^RNAi.UAS.cUa, Hsap\KRAS^G12D.UAS, Scer\GAL4^C-765 has partially lethal - majority die phenotype

(Das et al., 2021)

HDAC1^RNAi.UAS.cUa, Scer\GAL4^GMR.PF, lin-52^GD12885 has increased cell death phenotype

(Bhaskar et al., 2014)

Phenotype Manifest In

Suppressor of

Statement

Reference

HDAC1^RNAi.UAS.cUa, Scer\GAL4^C-765 is a suppressor | partially of wing vein | ectopic phenotype of Hsap\RAF1^L613V.UAS, Scer\GAL4^C-765

(Das et al., 2021)

HDAC1^RNAi.UAS.cUa, Scer\GAL4^C-765 is a suppressor | partially of wing vein | ectopic phenotype of Hsap\KRAS^G12D.UAS, Scer\GAL4^C-765

(Das et al., 2021)

Other

Statement

Reference

HDAC1^RNAi.UAS.cUa, Scer\GAL4^GMR.PF, lin-52^GD12885 has eye phenotype

(Bhaskar et al., 2014)

HDAC1^RNAi.UAS.cUa, Scer\GAL4^GMR.PF, lin-52^GD12885 has ommatidium phenotype

(Bhaskar et al., 2014)

HDAC1^RNAi.UAS.cUa, Scer\GAL4^GMR.PF, lin-52^GD12885 has interommatidial bristle phenotype

(Bhaskar et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of Rpd3^TRiP.cUa and lin-52^GD12885 together in the developing eye, under the control of Scer\GAL4^GMR.PF, results in a spotted eye phenotype. These eye-antennal discs display activation of hid, in cells adjacent to the morphogenetic furrow and extending further up to the distal end of the eye-antennal discs.

(Bhaskar et al., 2014)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

HDAC1^RNAi.UAS.cUa

HDAC1^TRiP.cUa

Rpd3^TRiP.cUa

Name Synonyms

Secondary FlyBase IDs

FBal0405875
FBal0303710

References (4)

Report Sections

Open Close