Frameshift deletion of base 4:137016 resulting in the addition of YIGGVIYIYMPLALNVHWRRQNRFW after valine 191 of the anne PD and PH isoforms (which corresponds to V54 of PA, PB and PF, V30 of PC and PI, V128 of PE and PG, V54 of PF) and premature truncation after these novel amino acids.