FB2026_02 , released June 18, 2026
Allele: Dmel\Top3βY332F.L
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General Information
Symbol
Dmel\Top3βY332F.L
Species
D. melanogaster
Name
FlyBase ID
FBal0408787
Feature type
allele
Associated gene
Dmel\Top3β
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
CRISPR/Cas9
(Lee et al., 2025)
gene targeting by homologous recombination
(Lee et al., 2025)
Progenitor genotype
Cytology
Description

Amino acid replacement: Y332F.

(Lee et al., 2025)

Y332F substitution in endogenous Top3β.

(Lee et al., 2025)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:6,286,327..6,286,327 [-]
Nucleotide change:

A6286327T

Reported nucleotide change:

??T

Amino acid change:

Y332F | Top3beta-PA; Y332F | Top3beta-PB

Reported amino acid change:

Y332F

(Lee et al., 2025)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Top3bY332F
      (Lee et al., 2025)
      Top3βY332F.L
      Name Synonyms
      Secondary FlyBase IDs
        References (1)