FB2026_03 , released September 17, 2026
Allele: Dmel\nAChRβ1A60T,R81E
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General Information
Symbol
Dmel\nAChRβ1A60T,R81E
Species
D. melanogaster
Name
FlyBase ID
FBal0408798
Feature type
allele
Associated gene
Dmel\nAChRβ1
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
CRISPR/Cas9
(Cheng et al., 2025)
gene targeting by homologous recombination
(Cheng et al., 2025)
Progenitor genotype
Cytology
Description

Amino acid replacement: A60T.

(Cheng et al., 2025)

Amino acid replacement: R81E.

(Cheng et al., 2025)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
MNV
3L:4,433,344..4,433,346 [+]
Nucleotide change:

CGT4433344GAA

Reported nucleotide change:

CGT?GAA

Amino acid change:

R81E | nAChRbeta1-PA

Reported amino acid change:

R81E

Comment:

Second of two point mutations in nAChRbeta1. The other is A60T.

(Cheng et al., 2025)
point_mutation
3L:4,432,499..4,432,499 [+]
Nucleotide change:

G4432499A

Reported nucleotide change:

G?A

Amino acid change:

A60T | nAChRbeta1-PA

Reported amino acid change:

A60T

Comment:

First of two point mutations in nAChRbeta1. The other is R81E.

(Cheng et al., 2025)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      nAChRβ1A60T,R81E
      β1A60T,R81E
      (Cheng et al., 2025)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)