FB2026_02 , released June 18, 2026
Allele: Dmel\LrrkhLRRK2.G2019S
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General Information
Symbol
Dmel\LrrkhLRRK2.G2019S
Species
D. melanogaster
Name
FlyBase ID
FBal0408889
Feature type
allele
Associated gene
Dmel\Lrrk
Associated Insertion(s)
TI{TI}LrrkhLRRK2.G2019S
Carried in Construct
Key Links
Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Pech et al., 2025)
Mutagen
phiC31 integrase
(Pech et al., 2025)
Progenitor genotype
TI{TI}LrrkKO
(Pech et al., 2025)
Associated Insertion(s)
TI{TI}LrrkhLRRK2.G2019S
Cytology
Description

The RMCE cassette present in TI{TI}LrrkKO has been has been replaced by cDNA sequence (followed by a polyA tail) encoding mutant Hsap\LRRK2 carrying the pathogenic G2019S variant, resulting in a locus in which the Hsap\LRRK2 coding sequence is expressed under the control of endogenous Lrrk regulatory sequences.

(Pech et al., 2025)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      LrrkhLRRK2.G2019S
      Name Synonyms
      Secondary FlyBase IDs
        References (1)