FlyBase Allele Report: Hsap\SLK[S781Y.UAS]

General Information

Symbol

Hsap\SLK^S781Y.UAS

Species

H. sapiens

Name

FlyBase ID

FBal0409194

Feature type

allele

Associated gene

Hsap\SLK

Associated Insertion(s)

Carried in Construct

P{UAS-hSLK.S781Y}

Key Links

Transgenic product class

missense_variant

(Alabdi et al., 2025)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

missense_variant

(Alabdi et al., 2025)

Mutagen

in vitro construct

(Alabdi et al., 2025)

Progenitor genotype

Carried in construct

P{UAS-hSLK.S781Y}

Cytology

Description

UASt regulatory sequences drive expression of Hsap\SLK cDNA carrying the S781Y mutation, relevant to human disease.

(Alabdi et al., 2025)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Hsap\SLK

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

This allele represents a human variant implicated in disease.

(Alabdi et al., 2025)

SLK:p.Ser781Tyr

(FlyBase curators, 2019-)

Variants Synonym(s)

Associated human disease model(s)

neurodevelopmental disorder, SLK-related

External database links

Comments concerning this variant

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Suppressor of

Statement

Reference

Hsap\SLK^S781Y.UAS, Scer\GAL4^elav.PLu is a non-suppressor of abnormal size | larval stage phenotype of Scer\GAL4^elav.PLu, Slik^HMC03770

(Alabdi et al., 2025)

Hsap\SLK^S781Y.UAS, Scer\GAL4^elav.PLu is a non-suppressor of abnormal larval locomotory behavior phenotype of Scer\GAL4^elav.PLu, Slik^HMC03770

(Alabdi et al., 2025)

Hsap\SLK^S781Y.UAS, Scer\GAL4^elav.PLu is a non-suppressor of decreased rate of adult locomotory behavior phenotype of Scer\GAL4^elav.PLu, Slik^HMC03770

(Alabdi et al., 2025)

Phenotype Manifest In

NOT Suppressor of

Statement

Reference

Hsap\SLK^S781Y.UAS, Scer\GAL4^elav.PLu is a non-suppressor of larval ventral nerve cord phenotype of Scer\GAL4^elav.PLu, Slik^HMC03770

(Alabdi et al., 2025)

Hsap\SLK^S781Y.UAS, Scer\GAL4^elav.PLu is a non-suppressor of NMJ bouton | larval stage phenotype of Scer\GAL4^elav.PLu, Slik^HMC03770

(Alabdi et al., 2025)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Hsap\SLK^S781Y.UAS

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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