FB2026_02 , released June 18, 2026
Allele: Dmel\Tmem43S333L
Open Close
General Information
Symbol
Dmel\Tmem43S333L
Species
D. melanogaster
Name
FlyBase ID
FBal0411016
Feature type
allele
Associated gene
Dmel\Tmem43
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
CRISPR/Cas9
(Jürgens et al., 2025)
Progenitor genotype
Cytology
Description

Amino acid replacement: S333L.

(Jürgens et al., 2025)

The S333L mutation is introduced into endogenous Tmem43; the mutation is orthologous to the pS358L mutation in the human gene.

(Jürgens et al., 2025)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      This allele represents a human variant implicated in disease.
      (Jürgens et al., 2025)
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      CG8111p.S333L
      (Jürgens et al., 2025)
      Dmel\Tmem43p.S333L
      (Jürgens et al., 2025)
      Tmem43S333L
      Tmem43p.S333L
      (Jürgens et al., 2026)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)