FB2026_03 , released September 17, 2026
Split System Combination: Scer\GAL4DBD.R18C11∩Hsap\RELAAD.R76F12
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General Information
Symbol
Scer\GAL4DBD.R18C11∩Hsap\RELAAD.R76F12
FlyBase ID
FBco0001734
Feature Type
split system combination
Component Alleles
Combination components
Component allele Hsap\RELAAD.R76F12
Component
Use(s)
Regulatory region(s)
GMR76F12
Encoded product / tool
p65(AD)::Zip+
Description

The GMR76F12 enhancer fragment followed by the Drosophila synthetic core promoter (DSCP) is fused upstream of the p65(AD)::Zip+ hemidriver (component of a 'split driver' system, contains the p65 activation domain).

(Rubin Laboratory at Janelia Farm, 2017)
Component allele Scer\GAL4DBD.R18C11
Component
Use(s)
Regulatory region(s)
GMR18C11
Encoded product / tool
GAL4(DBD)::Zip-
Description

The GMR18C11 enhancer fragment followed by the Drosophila synthetic core promoter (DSCP) is fused upstream of the GAL4(DBD)::Zip- hemidriver (component of the 'Split GAL4' system, contains the GAL4 DNA-binding domain).

(Rubin Laboratory at Janelia Farm, 2017)
Expression Data
Reporters Expression
distribution deduced from reporter (Gal4 UAS)
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult brain | restricted
(Hampel et al., 2015)
adult prothoracic neuromere | restricted
(Hampel et al., 2015)
antennal grooming descending neuron 2
(Hampel et al., 2015)
Additional Information
Statement
Reference

In a split-GAL4 system, HsapRELAAD.R76F12 drives expression in antennal grooming descending neuron 2, the prothoracic neuromere and lateral and dorsolateral parts of the brain when combined with ScerGAL4DBD.R18C11. Projections from antennal grooming descending neuron 2 were seen in close proximity to EcollexAGMR26B12 expressing antennal grooming descending neuron 2 and EcollexAGMR27H08 expressing zone C/E Johnston organ neurons. Positive GRASP (GFP reconstitution across synaptic partners) signals were seen between C/E Johnston organ neurons and ntennal grooming descending neuron 2 using these drivers.

(Hampel et al., 2015)

In a split-GAL4 system, ScerGAL4DBD.R18C11 drives expression in antennal grooming descending neuron 2, the prothoracic neuromere and lateral and dorsolateral parts of the brain when combined with HsapRELAAD.R76F12, in antennal grooming descending neuron 1 when combined with HsapRELAAD.R34C03 and antennal grooming descending neuron 2 when combined with HsapRELAAD.R76F12. Projections from antennal grooming descending neuron 2 were seen in close proximity to EcollexA[GMR26B12] expressing antennal grooming brain interneuron 2 and EcollexAGMR27H08 expressing zone C/E Johnston organ neurons. Positive GRASP (GFP reconstitution across synaptic partners) signals were seen between C/E Johnston organ neurons and ntennal grooming descending neuron 2 using these drivers.

(Hampel et al., 2015)
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External Crossreferences and Linkouts ( 0 )
References (1)