Gene Group: CLASS A GPCRs

General Information

Name

CLASS A GPCRs

Species

D. melanogaster

Symbol

GPCR-A

FlyBase ID

FBgg0000041

Date last reviewed

2013-08-15

Number of members

Description

Class A or rhodopsin-like GPCRs constitute the largest GPCR class. They share significant sequence homology to the light-activated GPCR, rhodopsin and contain a DRY motif in the third transmembrane domain. They include neuropeptide, hormone and nucleotide binding receptors. (Adapted from FBrf0193587 and PMID:15747061).

Notes on Group

Source Material

The CLASS A GPCRs Gene Group has been compiled using the following publication(s): Fujinaga et al., 2025, Schlichting et al., 2022, Qi et al., 2017, Xia et al., 2016, Hanlon and Andrew, 2015, Hilbrant et al., 2014, Bayliss et al., 2013, Collin et al., 2013, Gasque et al., 2013, Vogel et al., 2013, Caers et al., 2012, Ohhara et al., 2012, Posnien et al., 2012, Hansen et al., 2011, Ida et al., 2011, Veenstra, 2009, Yapici et al., 2008, Dolezelova et al., 2007, Garczynski et al., 2006, Hauser et al., 2006, Hauser et al., 2006, Hummel and Klämbt, 2006, Jorgensen et al., 2006, Cazzamali et al., 2005, Evans and Maqueira, 2005, Sudo et al., 2005, Park et al., 2003, and Brody and Cravchik, 2000 .

Key Gene Ontology (GO) terms

Molecular Function

G protein-coupled receptor activity

Biological Process

G protein-coupled receptor signaling pathway

Cellular Component

plasma membrane

Related Gene Groups

Parent group(s)

G PROTEIN COUPLED RECEPTORS

Component group(s)

AMINE RECEPTORS