FB2026_03 , released September 17, 2026
Gene Group: BCL-2 FAMILY
Open Close
General Information
Name
BCL-2 FAMILY
Species
D. melanogaster
Symbol
BCL2
FlyBase ID
FBgg0000061
Date last reviewed
2023-05-24
Number of members
3
Description
Description
The BCL-2 family are proteins that share up to four different BCL-2 homology (BH) motifs (BH1-BH4) within an alpha-helical bundle domain. Bcl-2 proteins can have pro- or anti-apoptotic activities. (Adapted from FBrf0187831 & PMID:26541461.)
Notes on Group

The BCL-2 family proteins can be grouped into three sub-families based on the number of BH (BCL-2 Homology) domains they share (PMID:19641503, FBrf0256347, PMID:26541461).

Source Material
The BCL-2 FAMILY Gene Group has been compiled using the following publication(s): Ikegawa et al., 2023, White, 2023, Kornbluth and White, 2005, and Igaki and Miura, 2004 .
Key Gene Ontology (GO) terms
Molecular Function
Biological Process
regulation of apoptotic process
Cellular Component
Related Gene Groups
Members (3)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Synonyms and Secondary IDs
Synonym(s)
BCL2
BCL-2 FAMILY
Bcl-2 homology domain family
Bcl-2-like proteins
Bcl2 family
Bcl-2
Bcl2-like
Secondary FlyBase ID(s)
References (5)