White, K. (2023). Sayonara to some evolutionary puzzles in the Bcl-2 family. EMBO J. 42(8): e113980.
FlyBase ID
FBrf0256347
Publication Type
Note
Abstract
BH3-only proteins are key regulators of Bcl-2 family members to activate apoptosis. The absence of a BH3-only protein in Drosophila has complicated the understanding of how Bcl-2 family members contribute to cell death in this model organism. Recent work published in The EMBO Journal reports on the identification of a BH3-only protein in flies. The reported findings may help to clarify the functional role and molecular mechanisms of the highly conserved Bcl-2 pathway in divergent organisms.
