FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Gene Group: INHIBITORY SERPINS
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General Information
Name
INHIBITORY SERPINS
Species
D. melanogaster
Symbol
I-SPN
FlyBase ID
FBgg0000067
Date last reviewed
2013-02-15
Number of members
17
Description
Description
The serpin family is a structurally-related group of secreted proteins containing the serpin-fold, a 350-400 amino acid domain. Serpins (SERine Protease INhibitors) were first identified as a set of proteins able to inhibit proteases, acting by forming a covalent complex is formed with the target proteinase targeting it for degradation. (Adapted from FBrf0213937 and FBrf0209216).
Notes on Group
Source Material
The INHIBITORY SERPINS Gene Group has been compiled using the following publication(s): Reichhart et al., 2011 and Garrett et al., 2009 .
Key Gene Ontology (GO) terms
Molecular Function
serine-type endopeptidase inhibitor activity
Biological Process
negative regulation of proteolysis
Cellular Component
Related Gene Groups
Parent group(s)
SERPINS
Members (17)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Synonyms and Secondary IDs
Synonym(s)
I-SPN
INHIBITORY SERPINS
Serine protease inhibitors
Serine peptidase inhibitors
Cysteine peptidase inhibitors
Spn
Serp
Srp
Secondary FlyBase ID(s)
References (3)