FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Complex: CYTOPLASMIC SMALL RIBOSOMAL SUBUNIT
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General Information
Name
CYTOPLASMIC SMALL RIBOSOMAL SUBUNIT
Species
D. melanogaster
Symbol
RPS
FlyBase ID
FBgg0000071
Date last reviewed
2025-06-09
Number of members
36
Description
Description
Cytoplasmic ribosomes are found on the endoplasmic reticulum and in the cytosol. They translate all mRNAs produced from nuclear genes and perform the majority of cellular protein synthesis. Ribosomes are formed by two ribonucleoprotein subunits, large and small. The principle function of the small subunit is to bind mRNA. (Adapted from FBrf0205398.)
Notes on Group

Cytoplasmic rRNAs are multicopy genes organised in tandem arrays (FBrf0202637). 18S rRNA (18SrRNA, SO:0002236) is associated with the small cytoplasmic ribosome.

In yeast, the majority of ribosomal proteins have paralogs due to genome duplications. In D.mel, six subunits of the cytosolic small ribosome are encoded by paralogs (RpS10a/RpS10b, RpS14a/RpS14b, RpS15Aa/RpS15Ab, RpS19a/RpS19b, RpS28-like/RpS28a/RpS28b and RpS5a/RpS5b). Of these, four genes display a testis-specific expression profile (RpS10a, RpS19b, RpS28-like and RpS28a) and have been used to create a CYTOPLASMIC SMALL RIBOSOMAL SUBUNIT - TESTIS-SPECIFIC VARIANT gene group. RpS5b has a strong, but not exclusive, bias for expression in the ovary.

Source Material
The CYTOPLASMIC SMALL RIBOSOMAL SUBUNIT Gene Group has been compiled using the following publication(s): Anger et al., 2013, Marygold et al., 2007, and Alonso and Santaren, 2006 .
Key Gene Ontology (GO) terms
Molecular Function
structural constituent of ribosome
Biological Process
cytoplasmic translation
Cellular Component
cytosolic small ribosomal subunit
cytosol
Related Gene Groups
Parent group(s)
CYTOPLASMIC RIBOSOMAL SUBUNITS
Members (36)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Equivalent Group(s)
Other resource(s)

[Ribosomal Protein Gene Database: D.MEL CYTOPLASMIC RIBOSOMAL PROTEINS](http://ribosome.med.miyazaki-u.ac.jp/rpg.cgi?mode=orglist&org=Drosophila%20melanogaster)

Synonyms and Secondary IDs
Synonym(s)
RPS
Small cytoplasmic ribosomal subunits
Small cytoribosome
Small ribosome
CYTOPLASMIC SMALL RIBOSOMAL SUBUNIT
CYTOPLASMIC SMALL RIBOSOMAL PROTEINS
Secondary FlyBase ID(s)
References (4)