FB2026_03 , released September 17, 2026
Gene Group: VACUOLAR ATPASE V1 DOMAIN SUBUNITS
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General Information
Name
VACUOLAR ATPASE V1 DOMAIN SUBUNITS
Species
D. melanogaster
Symbol
VHA-V1
FlyBase ID
FBgg0000073
Date last reviewed
2013-10-24
Number of members
14
Description
Description
The V1 domain of V-ATPases is a peripheral membrane domain composed of eight different subunits (A-H) that are expressed as multiple isoforms in a tissue-specific manner. The V1 domain is responsible for ATP hydrolysis - the A and B subunits form a hexameric ring and ATP hydrolysis occurs at catalytic sites contributed by the A subunits. The other V1 subunits provide regulatory functions and/or interact with the V0 domain. (Adapted from PMID:20450191 and FBrf0188241).
Notes on Group
Source Material
The VACUOLAR ATPASE V1 DOMAIN SUBUNITS Gene Group has been compiled using the following publication(s): Chintapalli et al., 2013, Allan et al., 2005, and Dow, 1999 .
Key Gene Ontology (GO) terms
Molecular Function
proton-transporting ATPase activity, rotational mechanism
Biological Process
proton transmembrane transport
Cellular Component
vacuolar proton-transporting V-type ATPase, V1 domain
Related Gene Groups
Parent group(s)
VACUOLAR ATPASE SUBUNITS
Component group(s)
VACUOLAR ATPASE V1 DOMAIN CATALYTIC SUBUNITS
VACUOLAR ATPASE V1 DOMAIN NON-CATALYTIC SUBUNITS
Members (14)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Synonyms and Secondary IDs
Synonym(s)
VHA-V1
VACUOLAR ATPASE V1 DOMAIN SUBUNITS
V1 SECTOR
V1
Secondary FlyBase ID(s)
References (5)