FB2026_02 , released June 18, 2026
Gene Group: N-ETHYLMALEIMIDE-SENSITIVE FACTORS
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General Information
Name
N-ETHYLMALEIMIDE-SENSITIVE FACTORS
Species
D. melanogaster
Symbol
NSF
FlyBase ID
FBgg0000114
Date last reviewed
2013-11-21
Number of members
3
Description
Description
The N-ethylmaleimide-sensitive factor/fusion protein (NSF), is a hexameric ATPase recruited to SNARE-SNAP complexes. ATP hydrolysis by NSF, leads to conformational changes and dissociation of the SNARE complex. (Adapted from FBrf0141270).
Notes on Group

In many eukaryotes there is a single NSF gene, in D.mel there are two.

Source Material
The N-ETHYLMALEIMIDE-SENSITIVE FACTORS Gene Group has been compiled using the following publication(s): Golby et al., 2001 .
Key Gene Ontology (GO) terms
Molecular Function
Biological Process
Cellular Component
Related Gene Groups
Parent group(s)
Members (3)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Synonyms and Secondary IDs
Synonym(s)
NSF
N-ETHYLMALEIMIDE-SENSITIVE FACTORS
NEM-sensitive fusion proteins
Secondary FlyBase ID(s)
References (3)