FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene Group: INHIBITOR OF APOPTOSIS UBIQUITIN LIGASES
Open Close
General Information
Name
INHIBITOR OF APOPTOSIS UBIQUITIN LIGASES
Species
D. melanogaster
Symbol
E3-IAP
FlyBase ID
FBgg0000191
Date last reviewed
2014-07-10
Number of members
2
Description
Description
E3 (ubiquitin) ligases interact with both ubiquitin-E2 (ubiquitin-conjugating) enzymes and the target protein, transferring the ubiquitin from the E2 to the substrate. Inhibitor of APoptosis (IAP) ubiquitin ligases are defined by the presence of one or more BIR (baculoviral IAP repeat) and a UBA (ubiquitin (Ub)-associated domain) domain that binds polyubiquitin and a RING finger domain. (Adapted from FBrf0216918).
Notes on Group

The IAP domain is also found in other proteins (see INHIBITOR OF APOPTOSIS gene group).

Source Material
The INHIBITOR OF APOPTOSIS UBIQUITIN LIGASES Gene Group has been compiled using the following publication(s): Darding and Meier, 2012, Vandenabeele and Bertrand, 2012, Du et al., 2011, and Ying et al., 2011 .
Key Gene Ontology (GO) terms
Molecular Function
ubiquitin protein ligase activity
Biological Process
protein ubiquitination
negative regulation of apoptotic process
Cellular Component
Enzymatic activity
Enzyme name (EC)
Related Gene Groups
Parent group(s)
RING DOMAIN E3 UBIQUITIN LIGASES
Other related group(s)
INHIBITOR OF APOPTOSIS
Members (2)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Equivalent Group(s)
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
E3-IAP
INHIBITOR OF APOPTOSIS UBIQUITIN LIGASES
Baculoviral IAP repeat containing ubiquitin ligase
BIRC E3
IAP E3
Secondary FlyBase ID(s)
References (6)