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General Information
Name
RETROMER
Species
D. melanogaster
Symbol
RETRO
FlyBase ID
FBgg0000196
Date last reviewed
2016-04-04
Number of members
7
Description
Description
The retromer coat complex is involved in the endosomal sorting of membrane proteins, particularly in the endosome-to-Golgi (retrograde) retrieval pathway. The complex can be divided into two subcomplexes, a cargo-selective trimer and a heterodimeric BAR-domain-containing sorting nexin complex that promotes formation of endosomal membrane tubules into which cargo proteins are sorted. (Adapted from PMID:23148298).
Notes on Group

The composition of the sorting nexin heterodimer may influence cargo selection. Snx1/Snx6 are thought of as the classical retromer complex sorting nexins. In D.mel, Snx3 is required for the endocytic recycling of wls (FBrf0216871).

Source Material
The RETROMER Gene Group has been compiled by FlyBase curators using the following publication(s): Li and Blissard, 2015, Maruzs et al., 2015, Koumandou et al., 2011, Koumandou et al., 2011, and Zhang et al., 2011 .
Key Gene Ontology (GO) terms
Molecular Function
Cellular Component
Related Gene Groups
Members (7)
For all members:
External Data
Equivalent Group(s)
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
RETRO
RETROMER
Retromer coat complex
Secondary FlyBase ID(s)
References (6)