FB2026_02 , released June 18, 2026
Complex: RETROMER COMPLEX
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General Information
Name
RETROMER COMPLEX
Species
D. melanogaster
Symbol
RETRO
FlyBase ID
FBgg0000196
Date last reviewed
2025-12-18
Number of members
5
Description
Description
The retromer coat complex is involved in the endosomal sorting of membrane proteins, particularly in the endosome-to-Golgi (retrograde) retrieval pathway. The complex can be divided into two subcomplexes, a cargo-selective trimer and a heterodimeric BAR-domain-containing sorting nexin complex that promotes formation of endosomal membrane tubules into which cargo proteins are sorted. (Adapted from PMID:23148298).
Notes on Group

The composition of the sorting nexin heterodimer may influence cargo selection. Snx1/Snx6 are thought of as the classical retromer complex sorting nexins.

In D.mel, Snx3 is required for the endocytic recycling of wls. As Snx3 is not included as a member of the RETROMER COMPLEX (FBrf0216871).

Source Material
The RETROMER COMPLEX Gene Group has been compiled using the following publication(s): Li and Blissard, 2015, Maruzs et al., 2015, Koumandou et al., 2011, Koumandou et al., 2011, and Zhang et al., 2011 .
Key Gene Ontology (GO) terms
Molecular Function
Cellular Component
Related Gene Groups
Members (5)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Synonyms and Secondary IDs
Synonym(s)
RETRO
Retromer coat complex
RETROMER COMPLEX
RETROMER
Secondary FlyBase ID(s)
References (6)