FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Complex: CYTOPLASMIC LARGE RIBOSOMAL SUBUNIT
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General Information
Name
CYTOPLASMIC LARGE RIBOSOMAL SUBUNIT
Species
D. melanogaster
Symbol
RPL
FlyBase ID
FBgg0000200
Date last reviewed
2025-06-09
Number of members
51
Description
Description
Cytoplasmic ribosomes are found on the endoplasmic reticulum and in the cytosol. They translate all mRNAs produced from nuclear genes and perform the majority of cellular protein synthesis. Ribosomes are formed by two ribonucleoprotein subunits, large and small. The principle function of the large subunit is to bind tRNA during the synthesis of polypeptides. (Adapted from FBrf0205398.)
Notes on Group

In yeast, the majority of ribosomal proteins have paralogs due to genome duplications. In D.mel, seven subunits of the cytosolic large ribosome are encoded by paralogs (RpLP0-like/RpLP0, RpL7/RpL7-like, RpL34b/RpL34a, RpL10Aa/RpL10Ab, RpL37-1/RpL37-2, RpL22/RpL22-like and RpL24-like/RpL24). Of these, three genes display a testis-specific expression profile (RpL10Aa, RpL37-2 and RpL22-like) and have been used to create a CYTOPLASMIC LARGE RIBOSOMAL SUBUNIT - TESTIS-SPECIFIC VARIANT gene group.

Source Material
The CYTOPLASMIC LARGE RIBOSOMAL SUBUNIT Gene Group has been compiled using the following publication(s): Anger et al., 2013, Marygold et al., 2007, and Alonso and Santaren, 2006 .
Key Gene Ontology (GO) terms
Molecular Function
structural constituent of ribosome
Biological Process
cytoplasmic translation
Cellular Component
cytosolic large ribosomal subunit
cytosol
Related Gene Groups
Parent group(s)
CYTOPLASMIC RIBOSOMAL SUBUNITS
Members (51)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Equivalent Group(s)
Other resource(s)

[Ribosomal Protein Gene Database: D.MEL CYTOPLASMIC RIBOSOMAL PROTEINS](http://ribosome.med.miyazaki-u.ac.jp/rpg.cgi?mode=orglist&org=Drosophila%20melanogaster)

Synonyms and Secondary IDs
Synonym(s)
RPL
Large Cytoplasmic Ribosomal subunit
Large Cytoribosome
Large ribosome
CYTOPLASMIC LARGE RIBOSOMAL PROTEINS
CYTOPLASMIC LARGE RIBOSOMAL SUBUNIT
Secondary FlyBase ID(s)
References (4)