Gene Group: PSEUDOKINASES

General Information

Name

PSEUDOKINASES

Species

D. melanogaster

Symbol

PSEUK

FlyBase ID

FBgg0000223

Date last reviewed

2022-10-31

Number of members

Description

Pseudokinases have a kinase domain but lack key residue(s) classically required for phosphotransfer. Although potentially lacking catalytic activity, pseudokinases may still have roles in signalling cascades and complexes. (Adapted from FBrf0209106, PMID:21074407 and PMID:23863165).

Notes on Group

p38c was thought to be a pseudokinase due to divergence in kinase motifs (FBrf0182691), but has shown to have kinase activity experimentally by FBrf0226357.

The Gyc76C and CG42637 transcription units are completely duplicated in the iso-1 reference strain genome. The duplication is a polymorphic variant that is present in the sequenced strain, but does not exist in other D.melanogaster strains (FBrf0211329).

Nipped-A (aka TRRAP) encodes a pseudokinase within the phosphatidylinositol 3-kinase related kinase (PIKK) family (PMID:31769470).

Slob was predicted to be a pseudokinase in FBrf0209106, but was shown to be active in FBrf0179534.

Wnk was predicted to be a pseudokinase in FBrf0209106, but was shown to be active in FBrf0222370.

The PSEUDOKINASES gene group is a collection of kinase domain containing proteins which lack or have been predicted to lack phosphotransferase activity. Pseudokinase classification by primary sequence may be unreliable - a good summary of the problems associated is provided by PMID:21074407.

Source Material

The PSEUDOKINASES Gene Group has been compiled using the following publication(s): Zaru and Marygold, 2025, Werner et al., 2024, Heidarian et al., 2023, Shekhar et al., 2023, Elías-Villalobos et al., 2019, Mele and Johnson, 2019, Reynaud et al., 2015, Sopko et al., 2014, Masoner et al., 2013, Okamoto et al., 2013, Petrova et al., 2013, Vogel et al., 2013, Cooper et al., 2010, Anamika et al., 2009, Biswas et al., 2009, Martinez Agosto and McCabe, 2006, Caruana, 2002, Hayashi et al., 2002, Manning et al., 2002, Halford and Stacker, 2001, and Persson et al., 1997 .

Key Gene Ontology (GO) terms

Molecular Function

Biological Process

Cellular Component

Related Gene Groups

Parent group(s)

PSEUDOENZYMES

Component group(s)

PSEUDO-GLYCEROL KINASE

PSEUDO-PYRUVATE KINASES

RECEPTOR GUANYLATE CYCLASES

RECEPTOR RELATED TO TYROSINE KINASE