Gene Group: ATYPICAL PROTEIN KINASES

General Information

Name

ATYPICAL PROTEIN KINASES

Species

D. melanogaster

Symbol

A-PK

FlyBase ID

FBgg0000233

Date last reviewed

2022-11-01

Number of members

Description

Atypical kinases are protein kinases or putative protein kinases that do not share clear sequence similarity with conventional eukaryotic protein kinases, but they or their orthologs have been shown experimentally to have protein kinase activity. Atypical kinases are defined in FBrf0201870.

Notes on Group

RhoGAP1A is related to the human BCR kinase, and KinBase includes RhoGAP1A (as well as human BCR and ABR) in the "Atypical -> BCR" group of kinases (http://kinase.com/web/current/kinbase/genes/Family/BCR/). However, RhoGAP1A (and ABR) lacks sequence conservation in the N-terminal kinase domain defined in BCR (e.g. PMID:8349582), and so RhoGAP1A is not included in the FlyBase ATYPICAL PROTEIN KINASES group.

Although KinBase includes Nipped-A (along with TRRAP genes from other species) in the "Atypical -> PIKK (phosphatidylinositol 3-kinase related kinase) -> TRRAP" group of kinases (http://kinase.com/web/current/kinbase/genes/Subfamily/TRRAP/), all TRRAP proteins are characterized as pseudokinases (PMID:31769470) and so Nipped-A is omitted from this group.

Source Material

The ATYPICAL PROTEIN KINASES Gene Group has been compiled using the following publication(s): Sopko et al., 2014, Ishikawa et al., 2012, Ishikawa et al., 2008, Chang et al., 2007, Manning et al., 2002, and Morrison et al., 2000 .

Key Gene Ontology (GO) terms

Molecular Function

protein kinase activity

Biological Process

protein phosphorylation

Cellular Component

Related Gene Groups

Parent group(s)

PROTEIN KINASES

Members (18)

For all members: