Gene Group: PROTEIN-LYSINE ACETYLTRANSFERASES

General Information

Name

PROTEIN-LYSINE ACETYLTRANSFERASES

Species

D. melanogaster

Symbol

KAT

FlyBase ID

FBgg0000317

Date last reviewed

2016-04-28

Number of members

Description

Lysine (K) acetyltransferases (KAT) transfer an acetyl group to ε-amino group of lysine residues. KATs have a long-established role as histone acetylases (HAT), but are now known to act on many non-histone proteins. (Adapted from FBrf0159755 and PMID:21075636).

Notes on Group

Human CLOCK has been shown to possess HAT activity. This has not been demonstrated for Clk and so it is not included within the LYSINE ACETYLTRANSFERASES gene group. (FBrf0204216 and PMID:18817890).

Not all 'putative KATs' listed in FBrf0227478 have been included in the LYSINE ACETYLTRANSFERASES gene group as no additional evidence was found to support their substrate specificity for lysine over other substrates.

Source Material

The PROTEIN-LYSINE ACETYLTRANSFERASES Gene Group has been compiled using the following publication(s): François et al., 2023, Antel et al., 2022, Feller et al., 2015, and Pandey et al., 2002 .

Key Gene Ontology (GO) terms

Molecular Function

protein-lysine-acetyltransferase activity

Biological Process

peptidyl-lysine acetylation

Cellular Component

nucleus

Enzymatic activity

Enzyme name (EC)

histone acetyltransferase (2.3.1.48)

Related Gene Groups

Parent group(s)