Gene Group: RAS SUPERFAMILY GTPASE ACTIVATING PROTEINS

General Information

Name

RAS SUPERFAMILY GTPASE ACTIVATING PROTEINS

Species

D. melanogaster

Symbol

RAS-SF-GAP

FlyBase ID

FBgg0000333

Date last reviewed

2015-08-06

Number of members

Description

The RAS superfamily of small GTPases are GDP/GTP-regulated molecular switches. GDP/GTP cycling is controlled by two main classes of regulatory protein: Guanine Nucleotide Exchange Factors (GEF) and GTPase Activating Proteins (GAP). Ras GTPases are active in their GTP bound form - GAPs accelerate the rate of GTP hydrolysis to bring about an end to activation. (Adapted from FBrf0158741 and PMID:15731001).

Notes on Group

Source Material

The RAS SUPERFAMILY GTPASE ACTIVATING PROTEINS Gene Group has been compiled using the following publication(s): Zeledon et al., 2019, Gabernet-Castello et al., 2013, Neisch et al., 2013, Laflamme et al., 2012, Yang and Terman, 2012, Diez et al., 2011, Greenberg and Hatini, 2011, van Dam et al., 2011, Bernards, 2003, and Zhang et al., 2003 .

Key Gene Ontology (GO) terms

Molecular Function

GTPase activator activity

Biological Process

Cellular Component

Related Gene Groups

Component group(s)

ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEINS

RAB GTPASE ACTIVATING PROTEINS

RAN GTPASE ACTIVATING PROTEINS

RAS GTPASE ACTIVATING PROTEINS

RHO GTPASE ACTIVATING PROTEINS