Gene Group: CYTOPLASMIC DYNEIN HEAVY CHAINS

General Information

Name

CYTOPLASMIC DYNEIN HEAVY CHAINS

Species

D. melanogaster

Symbol

DYNC

FlyBase ID

FBgg0000378

Date last reviewed

2016-01-21

Number of members

Description

Dynein heavy chains are minus end-directed microtubule motor proteins. Cytoplasmic dynein complexes are assembled from a cytoplasmic dynein heavy chain homodimer together with homodimeric intermediate chain, light-intermediate chain and light chain dynein subunits. Cytoplasmic dynein complexes participate in many cytoplasmic transport activities such as vesicle transport, organelle transport and mitotic spindle assembly. Some cytoplasmic dyneins specifically participate in intraflagellar transport. (Adapted from PMID:24064538).

Notes on Group

Although termed 'cytoplasmic' this refers to phylogenetic classification and the structural class of the dynein complex they assemble. The CYTOPLASMIC DYNEIN HEAVY CHAINS gene group also includes intraflagella transport dynein heavy chain subfamily (DYNC2H1, cytoplasmic dynein 2) that function in cargo transport within the cilium. This should not be confused with axonemal dyneins, that drive the bending motion of cilia. Cytoplasmic dyneins localized to the cytoplasm comprise the DYNC1H1 (cytoplasmic dynein 1) subfamily (PMID:24064538, FBrf0230622).

Source Material

The CYTOPLASMIC DYNEIN HEAVY CHAINS Gene Group has been compiled using the following publication(s): Wickstead and Gull, 2007, Pfister et al., 2006, Goldstein and Gunawardena, 2000, and Rasmusson et al., 1994 .

Key Gene Ontology (GO) terms

Molecular Function

minus-end-directed microtubule motor activity

Biological Process

microtubule-based movement

Cellular Component

cytoplasmic dynein complex

Related Gene Groups

Parent group(s)

DYNEIN HEAVY CHAINS

Members (2)

For all members: