Complex: CCR4-NOT COMPLEX

General Information

Name

CCR4-NOT COMPLEX

Species

D. melanogaster

Symbol

CCR4-NOT

FlyBase ID

FBgg0000469

Date last reviewed

Number of members

Description

The CCR4-NOT complex is a conserved complex implicated in various cellular processes to regulate gene expression. It is best characterised in its role as the main enzyme responsible for the deadenylation of mRNA. The conserved core of the complex is composed of two modules: the NOT module and a catalytic module comprising two deadenylases, twin and Pop2. (Adapted from FBrf0221179 and FBrf0231273).

Notes on Group

The ubiquitin ligase NOT4 is a component of the CCR4-NOT complex in Saccharomyces cerevisiae. Whereas the protein is conserved, it is not stably associated with the CCR4-NOT complex in flies or mammals (FBrf0211004, FBrf0225229). The NOT4 ortholog in D.mel Cnot4 is therefore not included in the CCR4-NOT COMPLEX gene group.

Source Material

The CCR4-NOT COMPLEX Gene Group has been compiled using the following publication(s): Temme et al., 2014, Bawankar et al., 2013, Temme et al., 2010, and Temme et al., 2004 .

Key Gene Ontology (GO) terms

Molecular Function

poly(A)-specific ribonuclease activity

Biological Process

negative regulation of translation

mRNA catabolic process

Cellular Component

CCR4-NOT complex

Enzymatic activity

Enzyme name (EC)

poly(A)-specific ribonuclease (3.1.13.4)

Related Gene Groups