FB2026_03 , released September 17, 2026
Gene Group: ANOCTAMINS
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General Information
Name
ANOCTAMINS
Species
D. melanogaster
Symbol
ANO
FlyBase ID
FBgg0000555
Date last reviewed
2025-01-21
Number of members
5
Description
Description
Anoctamins (or TMEM16 family members) are calcium-activated chloride channels (CaCC) with eight putative transmembrane domains. It is not clear whether all anoctamins possess CaCC activity. (Adapted from FBrf0223235 and PMID:25451786).
Notes on Group

CG15270 is included in the ANOCTAMINS gene group based on its sequence similarity to other members of this family and the presence of an Anoctamin InterPro domain, but there is no published data to support its inclusion.

Source Material
The ANOCTAMINS Gene Group has been compiled using the following publication(s): Jang et al., 2015, Wong et al., 2013, Galindo and Vacquier, 2005, and Ashburner et al., 1999.10.12 .
Key Gene Ontology (GO) terms
Molecular Function
intracellularly calcium-gated chloride channel activity
Biological Process
chloride transmembrane transport
Cellular Component
membrane
Related Gene Groups
Parent group(s)
CALCIUM-ACTIVATED CHLORIDE CHANNEL SUBUNITS
Members (5)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Synonyms and Secondary IDs
Synonym(s)
ANO
ANOCTAMINS
Transmembrane protein 16
Anion channels with eight transmembrane domains
TMEM16
Secondary FlyBase ID(s)
References (5)