FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene Group: GABA-GATED CHLORIDE CHANNEL SUBUNITS
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General Information
Name
GABA-GATED CHLORIDE CHANNEL SUBUNITS
Species
D. melanogaster
Symbol
GABA-CL
FlyBase ID
FBgg0000556
Date last reviewed
2023-11-21
Number of members
4
Description
Description
GABA-gated chloride channels mediate synaptic inhibition and regulate cellular excitability. GABA is the principal inhibitory neurotransmitter in the insect nervous system. Upon GABA binding the pore will open to allow chloride anions to pass, leading to hyperpolarization. (Adapted from FBrf0232136 and FBrf0228637).
Notes on Group

alka was moved from the GABA-GATED CHLORIDE CHANNEL SUBUNITS to the PH-SENSITIVE CHLORIDE CHANNEL SUBUNITS gene group based on experimental data in FBrf0256091.

Source Material
The GABA-GATED CHLORIDE CHANNEL SUBUNITS Gene Group has been compiled using the following publication(s): Remnant et al., 2016, Knipple and Soderlund, 2010, Schnizler et al., 2005, and Gisselmann et al., 2002 .
Key Gene Ontology (GO) terms
Molecular Function
GABA-gated chloride ion channel activity
Biological Process
Cellular Component
plasma membrane
Related Gene Groups
Parent group(s)
LIGAND-GATED CHLORIDE CHANNEL SUBUNITS
Members (4)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Equivalent Group(s)
Other resource(s)

[Transporter Classification Database:The Neurotransmitter Receptor, Cys loop, Ligand-gated Ion Channel (LIC) Family](https://tcdb.org/search/result.php?tc=1.A.9)

Synonyms and Secondary IDs
Synonym(s)
GABA-CL
GABA-GATED CHLORIDE CHANNEL SUBUNITS
Chloride gamma-aminobutyric acid-gated channels
Secondary FlyBase ID(s)
References (5)