Ligand-gated chloride channels (LGCC) are part of a larger superfamily of ligand-gated ion channels, which mediate the fast inhibitory and excitatory responses of neuronal and muscle cells to neurotransmitters. LGCC subunits have a common topology comprising four membrane-spanning segments and a large N-terminal extracellular domain with a conserved cysteine-bridge motif or Cys-loop. (Adapted from FBrf0232136, FBrf0180587 and FBrf0187801).