Gene Group: CHLORIDE CHANNEL SUBUNITS

General Information

Name

CHLORIDE CHANNEL SUBUNITS

Species

D. melanogaster

Symbol

CLC

FlyBase ID

FBgg0000553

Date last reviewed

2025-01-21

Number of members

Description

Chloride channels (CLC) are transmembrane channels that predominantly conduct Cl^-. Many CLCs are permeable to other anions, but mainly conduct Cl^- due to the higher concentration gradient. They are fundamental to many physiological processes such as neurotransmission, skeletal muscle contraction and volume homeostasis. (Adapted from PMID:26254230 and FBrf0232136).

Notes on Group

Source Material

The CHLORIDE CHANNEL SUBUNITS Gene Group has been compiled using the following publication(s): Leung et al., 2024, Menzies et al., 2024, Mi et al., 2023, Feingold et al., 2016, Remnant et al., 2016, Jang et al., 2015, Cabrero et al., 2014, Charroux and Royet, 2014, Chintapalli et al., 2013, Wong et al., 2013, Bhandari et al., 2012, Knipple and Soderlund, 2010, Littler et al., 2010, Hartzell et al., 2008, Littler et al., 2008, Pantazis et al., 2008, Chien and Hartzell, 2007, Rose et al., 2007, Suzuki, 2006, Galindo and Vacquier, 2005, Schnizler et al., 2005, Gisselmann et al., 2004, Dow and Davies, 2003, Gisselmann et al., 2002, Tavsanli et al., 2001, Ashburner et al., 1999.10.12, and Cully et al., 1996 .

Key Gene Ontology (GO) terms

Molecular Function

chloride channel activity

Biological Process

chloride transmembrane transport

Cellular Component

membrane

Related Gene Groups

Parent group(s)

ION CHANNELS BY CONDUCTANCE

Component group(s)

CALCIUM-ACTIVATED CHLORIDE CHANNEL SUBUNITS