Ubiquitin is a small (76 amino acid), highly conserved protein found in all eukaryotes. Through its covalent attachment to other proteins, ubiquitin can modify protein activity in numerous ways. The most well known is the targeting of proteins for proteasomal degradation. Ubiquitin is often expressed as a fusion protein, either as polyubiquitin or fused with the ribosomal proteins L40 and S27a. Ubiquitin monomers are generated by post-translational cleavage. (Adapted from PMID:12729753 and PMID:27012465)
Notes on Group
Compared to the paralogous polyubiquitin gene, Ubi-p5E, CG11700 has accumulated many non-synonymous substitutions after the duplication that occurred in the D.mel lineage (FBrf0218166).
