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General Information
Name
UBIQUITIN
Species
D. melanogaster
Symbol
UB
FlyBase ID
FBgg0000568
Date last reviewed
2016-10-18
Number of members
5
Description
Description

Ubiquitin is a small (76 amino acid), highly conserved protein found in all eukaryotes. Through its covalent attachment to other proteins, ubiquitin can modify protein activity in numerous ways. The most well known is the targeting of proteins for proteasomal degradation. Ubiquitin is often expressed as a fusion protein, either as polyubiquitin or fused with the ribosomal proteins L40 and S27a. Ubiquitin monomers are generated by post-translational cleavage. (Adapted from PMID:12729753 and PMID:27012465)

Notes on Group

Compared to the paralogous polyubiquitin gene, Ubi-p5E, CG11700 has accumulated many non-synonymous substitutions after the duplication that occurred in the D.mel lineage (FBrf0218166).

Source Material
The UBIQUITIN Gene Group has been compiled by FlyBase curators using the following publication(s): Lu et al., 2013, Zhan et al., 2012, Hoe et al., 2011, Marygold, 2007.1.12, and Izquierdo, 1994 .
Key Gene Ontology (GO) terms
Molecular Function
Biological Process
Cellular Component
Related Gene Groups
Members (5)
For all members:
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
ESTS:143G11T, ESTS:199A6T, Ubiquitin, Ub
Ribosomal protein S27A
DUb80, l(2)04820, mfs48, Ubiquitin, UB3-D
Ubiquitin-63E
Ub, ubiquitin, Ubi-p, polyubiquitin, ubi63E
External Data
Synonyms and Secondary IDs
Synonym(s)
UB
UBIQUITIN
Ubi
Secondary FlyBase ID(s)
References (6)