Gene Group: PHOSPHOLIPASE A2 ENZYMES

General Information

Name

PHOSPHOLIPASE A2 ENZYMES - CALCIUM INDEPENDENT

Species

D. melanogaster

Symbol

IPLA2

FlyBase ID

FBgg0000624

Date last reviewed

2022-05-09

Number of members

Description

The phospholipase A2 family of proteins catalyze the hydrolysis of the sn-2 ester bond of phospholipids to lysophospholipids and fatty acids. Calcium-independent members do not require calcium ions for their activity. (Adapted from FBrf0229704 and FBrf0161471.)

Notes on Group

sws has been excluded from the PHOSPHOLIPASE A2 ENZYMES - CALCIUM INDEPENDENT gene group, as it shows lysophospholipase activity and is a member of patatin-like phospholipase (PNPLA) domain containing protein family (see FBrf0206244 and FBrf0229704).

JMJD7 is listed as a calcium-independent phospholipase A2 in FBrf0161471 and FBrf0229704, but this appears to be an incorrect propagation from a previous error that human JMJD7 is an alternatively spliced isoform of PLA2G4B (see P0C870 entry at UniProt). JMJD7 is not included here.

Source Material

The PHOSPHOLIPASE A2 ENZYMES - CALCIUM INDEPENDENT Gene Group has been compiled using the following publication(s): Ben-David et al., 2015, Horne et al., 2009, and Renault et al., 2002 .

Key Gene Ontology (GO) terms

Molecular Function

A2-type glycerophospholipase activity

Biological Process

lipid catabolic process

Cellular Component

Enzymatic activity

Enzyme name (EC)

phospholipase A2 (3.1.1.4)

Related Gene Groups

Parent group(s)

PHOSPHOLIPASES A2