Gene Group: PHENOLOXIDASES

General Information

Name

PHENOLOXIDASES

Species

D. melanogaster

Symbol

FlyBase ID

FBgg0000723

Date last reviewed

2017-04-04

Number of members

Description

Phenoloxidases (POs) are innate immune proteins involved in the melanization process. POs catalyze the oxidation of phenols to quinones, which subsequently polymerize into melanin at the site of infection and around parasites. POs are synthesized as an inactive zymogen prophenoloxidase (PPO), which are cleaved to generate active POs. (Adapted from FBrf0224867 and FBrf0229770).

Notes on Group

A good summary of the role of PHENOLOXIDASES (POs) in melanin biosynthesis pathway can be found in Figure 2 of FBrf0215359.

Source Material

The PHENOLOXIDASES Gene Group has been compiled using the following publication(s): Dudzic et al., 2015, Chen et al., 2012, Li et al., 2012, Liu et al., 2012, and Tang, 2009 .

Key Gene Ontology (GO) terms

Molecular Function

catechol oxidase activity

Biological Process

melanization defense response

Cellular Component

extracellular region

Enzymatic activity

Enzyme name (EC)

catechol oxidase (1.10.3.1)

Related Gene Groups

Parent group(s)