The MADS box transcription factors are sequence-specific DNA binding proteins that regulate transcription. They have a conserved MADS-box motif. The N-terminal half of the motif has the DNA-binding specificity while the C-terminal half required for dimerisation. MADS-box proteins specifically recruit other transcription factors into multi-component regulatory complexes. (Adapted from PMID:7744019).
Notes on Group
The MADS-box motif name refers to four of the first members identified with this motif: MCM1, AG, DEFA and SRF (PMID:7744019).
Source Material
The
MADS-BOX TRANSCRIPTION FACTORS
Gene Group has been compiled using the following publication(s):
Han et al., 2004
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