FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene Group: FATTY ACYL-COA SYNTHETASES
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General Information
Name
FATTY ACYL-COA SYNTHETASES
Species
D. melanogaster
Symbol
ACS
FlyBase ID
FBgg0000835
Date last reviewed
2024-08-22
Number of members
24
Description
Description
Fatty acyl-coenzyme A (CoA) synthetases catalyze the "activation" of fatty acids by their thioesterification to CoA. This is the initial reaction in fatty acid metabolism, allowing their participation in many fundamental anabolic and catabolic pathways. (Adapted from FBrf0237395.)
Notes on Group

Although 'ebony' is included in the list of D. melanogaster 'Acyl-coenzyme A synthetases' in FBrf0237395 as part of the ACSF4 family, it is not included here. The ACSF4 family has since been been shown to have a different activity (see PMID: 24467666) and ebony is characterized as a beta-alanyl-biogenic amine synthetase (FBrf0178947).

Source Material
The FATTY ACYL-COA SYNTHETASES Gene Group has been compiled using the following publication(s): Watkins et al., 2007 and Oba et al., 2005 .
Key Gene Ontology (GO) terms
Molecular Function
fatty acid-CoA ligase activity
Biological Process
fatty acid metabolic process
Cellular Component
Related Gene Groups
Parent group(s)
CARBON-SULFUR LIGASES
Members (24)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Equivalent Group(s)
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
ACS
fatty acyl-coenzyme A synthetases
fatty acid CoA ligases
acyl-coenzyme A ligases
acid:CoA ligases
acyl coenzyme A synthetases
ACYL-COA SYNTHETASES
FATTY ACYL-COA SYNTHETASES
Secondary FlyBase ID(s)
References (4)