FB2026_03 , released September 17, 2026
Pathway: HIPPO SIGNALING PATHWAY
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General Information
Name
HIPPO SIGNALING PATHWAY
Species
D. melanogaster
Symbol
SWH
FlyBase ID
FBgg0000917
Date last reviewed
2025-06-11
Number of members
92
Description
Description
The Hippo signaling pathway is an intracellular kinase cascade in which hpo kinase in complex with sav, phosphorylates wts kinase which, in turn, phosphorylates yki transcriptional co-activator leading to its cytosolic retention. Activation of the Hippo pathway results in the down-regulation of cell proliferation and up-regulation of apoptosis, limiting tissue size. (Adapted from FBrf0224870).
Notes and selected reviews

Selected publications for background information: Upstream Regulation of the Hippo Size Control Pathway (FBrf0214165), Hippo Gains Weight: Added Insights and Complexity to Pathway Control (FBrf0224870), Mechanisms of Hippo pathway regulation (FBrf0230577), Tissue growth and tumorigenesis in Drosophila: cell polarity and the Hippo pathway (FBrf0236564), Upstairs, downstairs: spatial regulation of Hippo signalling (FBrf0238869).

Only genes that lie upstream of or directly influence yki cytosolic retention have been included in Hippo Signaling Pathway gene groups. Nuclear factors that regulate yki-mediated transcription or DNA-binding transcription factors that act with yki such as sd, tsh and hth (FBrf0209052) have not been included.

Biological Process Gene Ontology (GO) term(s)
Related Gene Groups
Physical Interaction Network
Members (92)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Synonyms and Secondary IDs
Synonym(s)
SWH
Salvador-Warts-Hippo pathway
SWH pathway
Hippo-Warts pathway
HIPPO SIGNALING PATHWAY
Hippo Signaling Pathway
Secondary FlyBase ID(s)
References (142)