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General Information
Name
ISOCITRATE DEHYDROGENASES
Species
D. melanogaster
Symbol
IDH
FlyBase ID
FBgg0001073
Date last reviewed
2021-03-02
Number of members
4
Description
Description
Isocitrate dehydrogenase (IDH) enzymes catalyze the oxidative decarboxylation of isocitrate to form α-ketoglutarate within the tricarboxylic acid (TCA) cycle. Mammalian IDH1 and IDH2 are NADP-dependent enzymes that exist as obligatory homodimers. Mammalian IDH3 is a mitochondrial, NAD-dependent heterotetramer comprising two catalytic alpha subunits together with regulatory beta and gamma subunits. Whereas IDH1/IDH2 reactions are both reversible, IDH3 strictly catalyzes the forward reaction, driving the TCA cycle by supplying α-ketoglutarate from the isocitrate pool. (Adapted from PMID:28375741 and PMID:28139779.)
Notes on Group

D. melanogaster Idh is the single ortholog of mammalian IDH1 and IDH2, whereas three distinct D. melanogaster genes (Idh3a, CG3483 and CG32026) appear to encode the catalytic alpha subunit of IDH3.

Source Material
The ISOCITRATE DEHYDROGENASES Gene Group has been compiled by FlyBase curators using the following publication(s): Alonso et al., 2005 .
Key Gene Ontology (GO) terms
Biological Process
Cellular Component
Enzymatic activity
Enzyme name (EC)
Isocitrate dehydrogenase (NAD(+)) (1.1.1.41)
Isocitrate dehydrogenase (NADP(+)) (1.1.1.42)
Related Gene Groups
Members (4)
For all members:
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Isocitrate dehydrogenase
IDH-NADP, l(3)L3852, ICDH, IDH1
Isocitrate dehydrogenase 3a
l(1)G0156, lethal (1) G0156
External Data
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
IDH
ISOCITRATE DEHYDROGENASES
Secondary FlyBase ID(s)
References (3)