Gene Group: RNA POLYMERASE CATALYTIC SUBUNITS

General Information

Name

RNA POLYMERASE CATALYTIC SUBUNITS

Species

D. melanogaster

Symbol

RNAPOL-C

FlyBase ID

FBgg0001250

Date last reviewed

2021-01-04

Number of members

Description

DNA-directed RNA polymerases (RNAPs) catalyze the synthesis of RNA from DNA templates. Nuclear DNA is transcribed by three different multi-subunit polymerases, RNAPs I, II and III, which synthesize mRNAs, rRNAs, tRNAs and other non-coding RNAs. Although composed of between 12-17 subunits, all three nuclear RNAPs contain a ten-subunit catalytic core. Mitochondrial RNA is synthesized by a single subunit RNA polymerase. DNA primases are a class of RNA polymerases that catalyse the synthesis of short RNA primers that are extended by DNA polymerases during DNA replication. (Adapted from PMID:22365827 and PMID:19540940.)

Notes on Group

The 'RNA polymerase catalytic subunits' group contains the core RNAP subunits defined in PMID:22365827, together with the DNA primase catalytic subunit and the single subunit mitochondrial RNAP.

Source Material

The RNA POLYMERASE CATALYTIC SUBUNITS Gene Group has been compiled using the following publication(s): Marygold et al., 2020 .

Key Gene Ontology (GO) terms

Molecular Function

DNA-directed RNA polymerase activity

Biological Process

RNA biosynthetic process

Cellular Component

Enzymatic activity

Enzyme name (EC)

DNA-directed RNA polymerase (2.7.7.6)

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